| Supplement | Amount | Why |
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Green Coffee Extract | Extract providing 400 to 450 mg of chlorogenic acids per day
|  [3 stars] Some controlled research has suggested that green coffee extracts taken as supplements or in food may support weight loss.
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Multivitamin | Daily multivitamin-mineral; follow label instructions
| [3 stars] Extra vitamins and minerals help ensure people get the nutrition they needs, especially people on a weight-loss diet who are avoiding certain foods.
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Pyruvate | 6 to 10 grams daily combined with an exercise program | [3 stars] Combining exercise with pyruvate may help speed up your metabolism. |
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5-HTP | Take under medical supervision: 600 to 900 mg daily for no more than 12 weeks
|  [2 stars] 5-HTP has been shown to reduce appetite and to promote weight loss. |
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7-KETO | 100 mg twice per day | [2 stars] 7-KETO has been shown to promote weight loss in overweight people. |
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Borage Oil | 5 grams (providing 890 mg of gamma-linolenic acid) per day
| [2 stars] In one study, supplementing with borage oil helped reduce the amount of weight regained by obese people who had previously shed pounds.
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Calcium | 800 mg daily | [2 stars] In a study of obese people following a low-calorie diet, those receiving a calcium supplement lost significantly more weight than those given a placebo. |
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Casein Protein | Refer to label instructions
| [2 stars] Casein protein in milk may aid weight loss due to its effect on appetite, calorie burning, and body composition.
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Cayenne | Add 6 to 10 grams to each meal | [2 stars] Incorporating cayenne pepper into the diet may promote weight loss by reducing hunger and calories consumed and increasing the calories the body burns. |
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Chitosan | Refer to label instructions
| [2 stars] Chitosan is a fiber-like substance that may reduce fat absorption. One study found it to be an effective weight-loss aid. |
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Conjugated Linoleic Acid | 3.2 to 4.2 grams daily | [2 stars] Though the evidence is conflicting, some studies have shown CLA to be effective at helping people lose body fat.
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Fiber | 5 to 7 grams daily | [2 stars] Several trials have shown that fiber supplementation from a variety of sources accelerated weight loss in people who were following a low-calorie diet. |
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Glucomannan | Adults: 3 to 4 grams daily; adolescents: 2 to 3 grams daily | [2 stars] Supplementing with glucomannan, a bulking agent, has promoted weight loss in overweight adults. |
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Green Tea | An extract supplying 270 mg of EGCG and 150 mg of caffeine per day | [2 stars] Green tea extract rich in polyphenols may support a weight-loss program by increasing energy expenditure or by inhibiting fat digestion. |
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HMB | 3 grams per day or 17 mg per pound of body weight per day | [2 stars] HMB may improve muscle growth and overall body composition when combined with an exercise program in people who are not already highly trained athletes. |
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Yohimbe | Take under medical supervision: enough to supply 5 mg of yohimbine four times per day | [2 stars] Yohimbine, a chemical found in yohimbe bark, may help weight loss by raising metabolic rate, reducing appetite, and increasing fat burning. |
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Amylase Inhibitors | Refer to label instructions
|  [1 star] Amylase inhibitors contain substances that prevent dietary carbohydrates from being absorbed by the body and may aid in weight loss. |
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Bitter Orange | Refer to label instructions
| [1 star] Bitter orange contains synephrine, which might promote weight loss.
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Blue-Green Algae | Refer to label instructions
| [1 star] Blue-green algae, or spirulina, is a rich source of protein, vitamins, minerals, and essential fatty acids. It has been promoted as a weight-loss aid, but this claim has not been proven by research.
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Chromium | Refer to label instructions
| [1 star] A review of several studies concluded that supplementing with chromium picolinate may have a beneficial effect on weight loss. |
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Coleus | Refer to label instructions
| [1 star] Coleus has been recommended by practitioners of herbal medicine for weight loss. |
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DHEA | Refer to label instructions
| [1 star] DHEA has been shown to help decrease body fat in men. |
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Fucoxanthin | Refer to label instructions
| [1 star] Animal studies suggest that fucoxanthin, an antioxidant found naturally in some types of seaweed, might prevent the growth of fat tissue and reduce abdominal fat.
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Guar Gum | Refer to label instructions
| [1 star] Guar gum, another type of fiber supplement, has not been effective in controlled studies for weight loss or weight maintenance. |
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Guaraná | Refer to label instructions
| [1 star] Guaraná contains caffeine and the closely related alkaloids theobromine and theophylline, these compounds may curb appetite and increase weight loss. |
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Guggul | Refer to label instructions
| [1 star] Coupled with exercise, a combination of guggul, phosphate salts, hydroxycitrate, and tyrosine was shown in one study to improve mood and weight loss in overweight adults. |
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Hoodia |
Read details for information
| [1 star] One study found hoodia to be effective at curbing appetite. |
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Hydroxycitric Acid | Refer to label instructions
| [1 star] HCA may aid in weight loss by suppressing appetite and by reducing the conversion of carbohydrates into stored fat. |
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L-Carnitine | Refer to label instructions
| [1 star] The amino acid L-carnitine is thought to be potentially helpful for weight loss because of its role in fat metabolism. |
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L-Tryptophan | Refer to label instructions
| [1 star] Animal research and preliminary human reports suggest that serotonin precursors such as L-tryptophan might help control appetite and promote weight loss.
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Relora | Refer to label instructions
| [1 star] Manufacturers of relora claim that the extract helps balance hormones such as cortisol, which are associated with weight gain. |
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Rice Protein | Refer to label instructions
| [1 star]
Dieters who are gluten or dairy sensitive and looking to supplement protein might consider rice protein, though its actual benefits for weight loss have not been studied.
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Sesamin | Refer to label instructions
| [1 star] Sesamin is substance present in sesame oil that manufacturers claim may enhance fat burning by increasing the activity of several liver enzymes that break down fatty acids,. |
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Soy | Refer to label instructions
| [1 star] Soy appears to have several effects on the body that might help with weight loss. |
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Whey Protein | Refer to label instructions
| [1 star] Whey protein may aid weight loss due to its appetite-suppressing effect. |
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